Thursday, July 24, 2014

Risk factors for proliferative diabetic retinopathy in a Latino American Population

This study, conducted as part of the Latino Americans in Los Angeles County study, assessed the personal and demographic risk factors for proliferative diabetic retinopathy in Latino Americans in Los Angeles County.

In this study, 729 subjects from Los Angeles County University of Southern California Medical Center (LAC + USC), Los Angeles, CA were recruited prospectively from the Center and affiliated clinics between June 2008 and June 2011. Complete personal data and results from systemic and ophthalmic examinations were collected for all enrolled subjects. Laboratory tests such as glycosylated hemoglobin, creatinine levels, and cholesterol levels were collected prospectively by drawing blood at the time of each patient's clinic visit. The main outcome measures were age, gender, type of diabetes mellitus (DM I or II), duration of diabetes mellitus, history of hypertension, history of insulin use, height, weight, and body mass index, smoking history, glycosylated hemoglobin, creatinine levels, and cholesterol levels.

The results indicated that the mean age of subjects with no diabetic retinopathy was 56.38 years, whereas that of patients with proliferative diabetic retinopathy was 57.43 years. Parameters that conferred a statistically significant increased risk for proliferative diabetic retinopathy included gender, with men at a higher risk), use of insulin, history of hypertension, and duration of more than 25 years versus 10–15 years of diabetes.

The authors conclude that duration of diabetes and male gender were found to be the strongest risk factor for development of proliferative diabetic retinopathy followed by insulin use and hypertension in this subset of population. They also found that smoking and glycosylated hemoglobin levels did not confer additional significant risk in this cohort.

Source

Notes: The outcomes seen in this study have been noticed in general population as well. Considering that food habits are changing, along with the increased level of stress and other factors, there is an increased prevalence of diabetes and hypertension in the population. These parameters are important for populations living in countries where routine retinal care is not available to most of the population, such as Honduras and Belize, or in Ethiopia. 

Smoking has not been found to be an important risk factor for diabetic retinopathy in other studies as well (Diabetes care). But considering smoking is an important predisposing factor for other important diseases, the outcome does not mean a person afflicted with diabetes can smoke!

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