Human blindness could be cured utilizing Zebrafish's capability to regenerate its retina

Researchers are looking into how a unique characteristic of a zebrafish can regenerate retinas in humans and keep people seeing as they age.

Zebrafish might be tiny, but they come with some supersized powers. But unlike mammals, they are able to regenerate parts of their retina if they become injured. That is why researchers from Vanderbilt University Medical Center are studying how this characteristic of zebrafish can help humans dealing with age-related vision loss due to damage to the retina.

Low-Cost OCT Retinal Scanner Could Help Prevent Blindness Worldwide

(c) Duke University

Biomedical engineers at Duke University have developed a low-cost, portable optical coherence tomography (OCT) scanner that promises to bring the vision-saving technology to underserved regions throughout the United States and abroad.

Thanks to a redesigned, 3D-printed spectrometer, the scanner is 15 times lighter and smaller than current commercial systems and is made from parts costing less than a tenth the retail price of commercial systems—all without sacrificing imaging quality.

A US Court Asks Stem Cell Clinics to Stop Manufacturing and Marketing Products without Regulatory approval

(c) The Atlantic

U.S. District Judge Ursula Ungaro of the Southern District of Florida has issued an order that stops US Stem Cell Clinic LLC, of Weston, Florida, and US Stem Cell Inc., of Sunrise, Florida, and their Chief Scientific Officer Kristin Comella, Ph.D., from manufacturing or distributing any and all stromal vascular fraction (SVF) products, which are adipose (fat) tissue derived stem cell products, until they come into compliance with the law.

Immune system may slow degenerative eye disease

A new study shows that the complement system, part of the innate immune system, plays a protective role to slow retinal degeneration in a mouse model of retinitis pigmentosa, an inherited eye disease. This surprising discovery contradicts previous studies of other eye diseases suggesting that the complement system worsens retinal degeneration. 

The research was performed by scientists at the National Eye Institute (NEI), part of the National Institutes of Health, and appears in the Journal of Experimental Medicine.

Neovascular AMD: Bevacizumab Injection Increases Angiogenic Biomarkers

Dr. Thiago Cabral

Neovascular age-related macular degeneration (nAMD) is induced by the development of new abnormal ‘leaky’ blood vessels in the choroid and retina, when the balance of pro- and anti-angiogenic factors is upset. Vascular endothelial growth factor (VEGF) is considered a critical modulator of angiogenesis and is related to induction of endothelial cell migration and proliferation after hypoxia. The development of anti-VEGF agents, such as bevacizumab (Avastin®), ranibizumab (Lucentis®) and aflibercept (Eylea®), revolutionized the treatment of nAMD.

Significant Visual Improvement Reported in Patients with Retinitis Pigmentosa in a cell therapy clinical trial

(c) ReNeuron

ReNeuron Group plc, a UK-based company focused on development of cell-based therapeutics, has announced encouraging results from an early stage trial of its cell therapy for retinitis pigmentosa (RP), which, if approved, could be a competitor to Spark/Novartis’s Luxturna (voretigene neparvovec). Unlike the already-approved gene therapy Luxturna, ReNeuron’s cell-based therapy would not be limited to patients with a disease caused by a certain mutation.

Injection Improves Vision in a Form of Childhood Blindness

(c) NIH

A new treatment for patients with a form of congenital retinal blindness has shown success in improving vision, according to results published today in Nature Medicine led by researchers at the Scheie Eye Institute  in the Perelman School of Medicine at the University of Pennsylvania.